[1-(4-Trifluoromethyl-phenyl)-cyclopentyl]-methanol → (1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methanol

HRID 2169486Notes

Reaction equation

HRID 2169486 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([CH:18]=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.FC(F)(F)C1C=CC(C2(CO)CCCC2)=CC=1>>[F:1][C:2]([F:20])([F:21])[C:3]1[CH:4]=[C:5]([C:13]2([CH2:18][OH:19])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

3

Reactant 2

HCID 86725928[1-(4-Trifluoromethyl-phenyl)-cyclopentyl]-methanolHCID 867261091-(3,5-Bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde

Product 1

HCID 10335667(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methanol

Procedure

(1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methanol (457) was synthesized as a colourless liquid from 1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde (456) following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentane-methanol (239).

Sources & evidence

ORD record
ord-2dfa4820d93841db86bf2678c66620b1
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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