[1-(4-Trifluoromethyl-phenyl)-cyclopentyl]-acetonitrile → 2-(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)acetonitrile

HRID 2169488Notes

Reaction equation

HRID 2169488 reaction equation
CS(O[CH2:6][C:7]1([C:12]2[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[C:14]([C:22]([F:25])([F:24])[F:23])[CH:13]=2)[CH2:11][CH2:10][CH2:9][CH2:8]1)(=O)=O.FC(F)(F)C1C=CC(C2(C[C:40]#[N:41])CCCC2)=CC=1>>[F:20][C:18]([F:19])([F:21])[C:16]1[CH:17]=[C:12]([C:7]2([CH2:6][C:40]#[N:41])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:13]=[C:14]([C:22]([F:24])([F:25])[F:23])[CH:15]=1

Participants

3

Reactant 2

HCID 86725930[1-(4-Trifluoromethyl-phenyl)-cyclopentyl]-acetonitrileHCID 86726110(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonate

Product 1

HCID 867261112-(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)acetonitrile

Procedure

2-(1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)acetonitrile (459) was synthesized as a brown solid from (1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonate (458) following the procedure described for [1-(4-trifluoromethyl-phenyl)-cyclopentyl]-acetonitrile (241).

Sources & evidence

ORD record
ord-800d7a4873b440d38d259ccb77f890e1
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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