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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169488Generated: October 30, 2026

[1-(4-Trifluoromethyl-phenyl)-cyclopentyl]-acetonitrile → 2-(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)acetonitrile

https://huagongshe.com/reaction/2169488

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[1-(4-Trifluoromethyl-phenyl)-cyclopentyl]-acetonitrileHCID 86725930—
Reactant(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonateHCID 86726110—
Product2-(1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentyl)acetonitrileHCID 86726111—

Reaction Steps

2-(1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)acetonitrile (459) was synthesized as a brown solid from (1-(3,5-bis(trifluoromethyl)phenyl)cyclopentyl)methyl methanesulfonate (458) following the procedure described for [1-(4-trifluoromethyl-phenyl)-cyclopentyl]-acetonitrile (241).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045486B2
Source datasetuspto-grants-2015_06
ORD IDord-800d7a4873b440d38d259ccb77f890e1
Source noteuspto-grants-2015_06