2-(1-(3-Chlorophenyl)-cyclopentyl)-acetamidine hydrochloride → HCID 178450809, compound

HRID 2169521Notes

Reaction equation

HRID 2169521 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][C:15]([NH2:17])=[NH:16])[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[C:18]([O:22][C:23]([C:25]1[C:30]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[C:29]([OH:39])N=C(CC2(C3C=CC(C(F)(F)F)=CC=3)CCCC2)N=1)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[CH2:32]([O:31][C:30]1[C:25]([C:23]([O:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:24])=[N:16][C:15]([CH2:14][C:9]2([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([Cl:2])[CH:4]=3)[CH2:13][CH2:12][CH2:11][CH2:10]2)=[N:17][C:29]=1[OH:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 867261412-(1-(3-Chlorophenyl)-cyclopentyl)-acetamidine hydrochlorideHCID 178450810HCID 178450810, compound

Product 1

HCID 178450809HCID 178450809, compound

Procedure

tert-butyl 5-(benzyloxy)-2-((1-(3-chlorophenyl)cyclopentyl)methyl)-6-hydroxypyrimidine-4-carboxylate (500) was synthesized as a white solid from 2-(1-(3-chlorophenyl)-cyclopentyl)-acetamidine hydrochloride (499) following the procedure described for 5-benzyloxy-2-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester (243).

Sources & evidence

ORD record
ord-4ac76826633a445f940cead8c28fc70d
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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