HRID2169521

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID86726141

未命名化合物

结构：CC(C)(C)OC(=O)c1nc(CC2(c3ccc(C(F)(F)F)cc3)CCCC2)nc(O)c1OCc1ccccc1

HCID178450810

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)c1nc(CC2(c3cccc(Cl)c3)CCCC2)nc(O)c1OCc1ccccc1

HCID178450809

未命名化合物

PROCEDURE

实验过程

tert-butyl 5-(benzyloxy)-2-((1-(3-chlorophenyl)cyclopentyl)methyl)-6-hydroxypyrimidine-4-carboxylate (500) was synthesized as a white solid from 2-(1-(3-chlorophenyl)-cyclopentyl)-acetamidine hydrochloride (499) following the procedure described for 5-benzyloxy-2-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester (243).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ac76826633a445f940cead8c28fc70d
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045486B2
来源说明: uspto-grants-2015_06

反应 SMILES

Cl.[Cl:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:14][C:15]([NH2:17])=[NH:16])[CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[C:18]([O:22][C:23]([C:25]1[C:30]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[C:29]([OH:39])N=C(CC2(C3C=CC(C(F)(F)F)=CC=3)CCCC2)N=1)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[CH2:32]([O:31][C:30]1[C:25]([C:23]([O:22][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:24])=[N:16][C:15]([CH2:14][C:9]2([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([Cl:2])[CH:4]=3)[CH2:13][CH2:12][CH2:11][CH2:10]2)=[N:17][C:29]=1[OH:39])[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1