反应详情

The title compound was prepared in a manner similar to EXAMPLE 84 using 2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one (PREPARATION x1, 50 mg, 0.208 mmol), benzo[d][1,3]dioxol-4-ylboronic acid (51.7 mg, 0.312 mmol) and PdCl2(dppf) (7.60 mg, 10.39 μmol) in dioxane (2 mL) and aqueous saturated NaHCO3 (0.4 mL). 1H NMR (400 MHz, DMSO-d6) δ 2.96-3.09 (m, 1 H), 3.62 (m, 2 H), 3.93-4.01 (m, 1 H), 4.11-4.20 (m, 1 H), 4.36-4.46 (m, 1 H), 4.52-4.62 (m, 1 H), 6.12 (s, 2 H), 6.94 (t, 1 H), 7.02 (m, 1 H), 7.58-7.65 (m, 1 H), 7.83 (s, 1 H), 10.98 (s, 1H). ESI-MS m/z [M+H]+ calc'd for C16H14N4O4, 327.10; found 327.3.