反应详情

温度

10 °C

To a solution of crude 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one (Example 31, step (ii), 53 g) in acetone (600 mL) was added aqueous HCl solution (2M, 600 mL) and the solution was heated at reflux for 18 h. The solution was concentrated under vacuum to remove acetone and then cooled to 10° C. The resulting precipitate was filtered and dried under vacuum to afford the sub-titled compound (26.8 g).

1. temperaturethe solution was heated
2. temperatureat reflux for 18 h
3. concentrationThe solution was concentrated under vacuum
4. customto remove acetone
5. filtrationThe resulting precipitate was filtered
6. customdried under vacuum