反应详情

Methyl 5-bromo-3-methylpicolinate (800 mg) in dichloromethane (5 mL) was treated with N-bromosuccinimide (619 mg) and AIBN (14.28 mg). The mixture was stirred and irradiated with a 500 W halogen lamp for 3.5 h. The reaction mixture was cooled and diluted with dichloromethane, and washed with water. The organic layer was dried over magnesium sulfate, filtered and evaporated to afford the sub-titled compound (1036 mg).

1. temperatureThe reaction mixture was cooled
2. washwashed with water
3. dry with materialThe organic layer was dried over magnesium sulfate
4. filtrationfiltered
5. customevaporated