2-Amino-6-fluorobenzonitrile → N-(1-(3-amino-2-cyanophenoxy)-2-methylpropan-2-yl)cyclohexanecarboxamide

HRID 2169887Notes

Reaction equation

HRID 2169887 reaction equation
[OH:1][CH2:2][C:3]([NH:6][C:7]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:8])([CH3:5])[CH3:4].[NH2:15][C:16]1[CH:23]=[CH:22][CH:21]=[C:20](F)[C:17]=1[C:18]#[N:19]>>[NH2:15][C:16]1[C:17]([C:18]#[N:19])=[C:20]([CH:21]=[CH:22][CH:23]=1)[O:1][CH2:2][C:3]([NH:6][C:7]([CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:8])([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 5226592-Amino-6-fluorobenzonitrileHCID 39240152N-(1-hydroxy-2-methylpropan-2-yl)cyclohexanecarboxamide

Product 1

HCID 66745570N-(1-(3-amino-2-cyanophenoxy)-2-methylpropan-2-yl)cyclohexanecarboxamide

Procedure

Prepared as in Example 22b from N-(1-hydroxy-2-methylpropan-2-yl)cyclohexanecarboxamide (Example 37c) and 2-amino-6-fluorobenzonitrile as an off-white solid (29%). MS 316 (MH+).

Sources & evidence

ORD record
ord-980e3b4ea24a435c8d6578666677808f
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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