Cyclohexanecarboxylic acid → N-(1-hydroxy-2-methylpropan-2-yl)cyclohexanecarboxamide

HRID 2169888Notes

Reaction equation

[CH:1]1([C:7]([OH:9])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:10][C:11]([CH3:15])([CH3:14])[CH2:12][OH:13]>>[OH:13][CH2:12][C:11]([NH:10][C:7]([CH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1)=[O:9])([CH3:15])[CH3:14]

Participants

Reactant 2

HCID 7413Cyclohexanecarboxylic acid

HCID 118072-Amino-2-methyl-1-propanol

Product 1

HCID 39240152N-(1-hydroxy-2-methylpropan-2-yl)cyclohexanecarboxamide

Procedure

Prepared as in Example 24a from cyclohexanecarboxylic acid and 2-amino-2-methylpropan-1-ol as a colorless oil (15%). MS 200 (MH+).

Sources & evidence

ORD record: ord-33a54dc3dcc347f790f21310506733a6
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09049878B2

Reaction notes

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