Ethyl Acetoacetate → HCID 66747338, compound

HRID 2169963Notes

Reaction equation

HRID 2169963 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]2[CH2:12][CH2:11]2)[C:3]=1[C:4]#[N:5].O=[C:14]([CH3:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[CH:7][C:6]=2[CH:10]2[CH2:11][CH2:12]2)[N:1]=[C:14]([CH3:21])[C:15]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 667472522-Amino-6-cyclopropylbenzonitrile

Product 1

HCID 66747338HCID 66747338, compound

Procedure

Prepared as in Example 2a from 2-amino-6-cyclopropylbenzonitrile (Tachdjian, C. et al. PCT Int. Appl. 2008, WO 2008154221) and ethyl 3-oxobutanoate as a pale yellow solid (80%). MS 271 (MH+).

Sources & evidence

ORD record
ord-a5e24425448e414d98d3a885198cd2df
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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