Ethyl Acetoacetate → HCID 66746776, compound

HRID 2169967Notes

Reaction equation

HRID 2169967 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)[C:3]=1[C:16]#[N:17].O=[C:19]([CH3:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[NH2:17][C:16]1[C:3]2[C:2](=[CH:7][CH:6]=[CH:5][C:4]=2[C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[CH:9]=2)[N:1]=[C:19]([CH3:26])[C:20]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22]

Participants

3

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 66747101HCID 66747101, compound

Product 1

HCID 66746776HCID 66746776, compound

Procedure

Prepared as in Example 2a from 3-amino-3′-methoxy-[1,1′-biphenyl]-2-carbonitrile (Example 114b) and ethyl 3-oxobutanoate as a pale yellow solid (55%). MS 337 (MH+).

Sources & evidence

ORD record
ord-59962207ffb94717994dbfc500d927e6
Source dataset
uspto-grants-2015_06
Patent number
US09049878B2

Reaction notes

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