Benzyl Alcohol → HCID 178440861, compound

HRID 2170015Notes

Reaction equation

HRID 2170015 reaction equation
[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Sr+2:13].[O:14]=[C:15]1[O:21][C@H:20]([C@H:22]([CH2:24][OH:25])[OH:23])[C:18]([O-:19])=[C:16]1[OH:17].S([O-])(OCCCCCCCCCCCC)(=O)=O.[Na+].[CH3:44][CH:45]([CH2:47][C:48]1[CH:53]=[CH:52][C:51]([CH:54]([C:56]([OH:58])=[O:57])[CH3:55])=[CH:50][CH:49]=1)[CH3:46].C(O)C1C=CC=CC=1>C(O)(C)C>[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Sr+2:13].[OH:58][C:56]([CH:54]([C:51]1[CH:50]=[CH:49][C:48]([CH2:47][CH:45]([CH3:44])[CH3:46])=[CH:53][CH:52]=1)[CH3:55])=[O:57].[O:14]=[C:15]1[O:21][C@H:20]([C@H:22]([CH2:24][OH:25])[OH:23])[C:18]([O-:19])=[C:16]1[OH:17]

Participants

6

Reactant 4

HCID 244Benzyl AlcoholHCID 3672Ibuprofen, (+-)-3×HCID 3423265Sodium Lauryl SulfateHCID 140483007strontium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate)

Product 1

HCID 178440861HCID 178440861, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Strontium ascorbate (900 mg) from Example 8 and sodium lauryl sulphate (450 mg) were mixed into Ibux gel 5% (produced by Weifa AS, Oslo, Norway) using a mortar and pestle. (Ibux gel contains 5% ibuprofen in a hydrogel comprising hydroxyethylcellulose, benzylalcohol, isopropanol, sodium hydroxyl and purified water). The resulting gel contained 1.2% wt strontium.

Workup

  1. custompurified water)

Sources & evidence

ORD record
ord-45996a62a26144f194bb2d119e9f8841
Source dataset
uspto-grants-2015_06
Patent number
US09050312B2

Reaction notes

Loading…