Hydrochloric Acid → HCID 178508778, compound

HRID 2170086Notes

Reaction equation

HRID 2170086 reaction equation
C([O:5][C:6](=[O:42])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([N:19]2[CH2:40][CH2:39][C:22]3([NH:26]/[C:25](=[N:27]/[C:28]([C:30]4[C:35]([NH2:36])=[N:34][C:33]([NH2:37])=[C:32]([Cl:38])[N:31]=4)=[O:29])/[NH:24][CH2:23]3)[CH2:21][CH2:20]2)=[O:18])=[CH:11][C:10]=1[Cl:41])(C)(C)C.Cl>O1CCOCC1>[Cl:41][C:10]1[CH:11]=[C:12]([CH2:15][CH2:16][C:17]([N:19]2[CH2:20][CH2:21][C:22]3([NH:26]/[C:25](=[N:27]/[C:28]([C:30]4[C:35]([NH2:36])=[N:34][C:33]([NH2:37])=[C:32]([Cl:38])[N:31]=4)=[O:29])/[NH:24][CH2:23]3)[CH2:39][CH2:40]2)=[O:18])[CH:13]=[CH:14][C:9]=1[O:8][CH2:7][C:6]([OH:42])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451331HCID 178451331, compound

Product 1

HCID 178508778HCID 178508778, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

[2-Chloro-4-(3-{2-[(E)-3,5-diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]dec-8-yl}-3-oxo-propyl)-phenoxy]-acetic acid tert-butyl ester (step 1) (5.3 g, 8.53 mmol) was suspended in 1,4-dioxane (25 ml) and treated with 4N HCl in dioxane (30 ml). The reaction mixture was stirred at RT for 24 h and filtered. The solid was washed with iso-hexane (300 ml) to afford the title compound as a hydrochloride salt;

Workup

  1. filtrationfiltered
  2. washThe solid was washed with iso-hexane (300 ml)

Sources & evidence

ORD record
ord-b789701b823a4d6383e5640ba2fb7354
Source dataset
uspto-grants-2015_06
Patent number
US09050339B2

Reaction notes

Loading…