Hydrochloric Acid → N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochloride

HRID 2170310Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2170310
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:25][C:26](=[O:28])[CH3:27])=[N:6][C:7]=1[C@@H:8]([NH:18]S(C(C)(C)C)=O)[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1.[ClH:29]>CO.O1CCOCC1>[ClH:29].[NH2:18][CH:8]([C:7]1[N:6]=[C:5]([NH:25][C:26](=[O:28])[CH3:27])[CH:4]=[CH:3][C:2]=1[Br:1])[CH2:9][C:10]1[CH:11]=[C:12]([F:17])[CH:13]=[C:14]([F:16])[CH:15]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric Acid2×HCID 90280239(S)-N-(5-bromo-6-(2-(3,5-difluorophenyl)-1-(1,1-dimethylethylsulfinamido)ethyl)pyridin-2-yl)acetamide

Produkt 1

HCID 90280406N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

(S)—N-(5-Bromo-6-(2-(3,5-difluorophenyl)-1-(1,1-dimethylethylsulfinamido)ethyl)pyridin-2-yl)acetamide (1E, crude material from last step) was treated with a mixture of 2 ml of 1.25 M HCl in MeOH (methanol)/1 ml of 4 M HCl in dioxane for 1 hour. The solvent was removed in vacuo. The crude material was used without further purification. MS (m/z) 369.9 [M+H]+.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customThe crude material was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c92722d8948348039597bb61502f84d0
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09050344B2

Notizen zur Reaktion

Wird geladen…