N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochloride → (R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride

HRID 2170322Notes

Reaction equation

HRID 2170322 reaction equation
[ClH:1].NC(C1N=C(NC(=O)C)C=CC=1Br)CC1C=C(F)C=C(F)C=1.[Br:24][C:25]1[C:26]([C@H:33]([NH:43][S@](C(C)(C)C)=O)[CH2:34][C:35]2[CH:40]=[C:39]([F:41])[CH:38]=[C:37]([F:42])[CH:36]=2)=[N:27][C:28]([S:31][CH3:32])=[N:29][CH:30]=1>>[ClH:1].[Br:24][C:25]1[C:26]([C@H:33]([NH2:43])[CH2:34][C:35]2[CH:40]=[C:39]([F:41])[CH:38]=[C:37]([F:42])[CH:36]=2)=[N:27][C:28]([S:31][CH3:32])=[N:29][CH:30]=1

Participants

3

Reactant 2

HCID 90280406N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochlorideHCID 90312182(S)-N-((R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide

Product 1

HCID 90312062(R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride

Procedure

The title compound (11F) was prepared according to the method presented for the synthesis of compound 1F of Example 1 utilizing 11E. MS (m/z) 361.66 [M+H]+.

Sources & evidence

ORD record
ord-3f79cf2465e645d090f8d855c1d7b50c
Source dataset
uspto-grants-2015_06
Patent number
US09050344B2

Reaction notes

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