N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochloride → (R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	N-(6-(1-amino-2-(3,5-difluorophenyl)ethyl)-5-bromopyridin-2-yl)acetamide hydrochloride	HCID 90280406	—
Reactant	(S)-N-((R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)-2-methylpropane-2-sulfinamide	HCID 90312182	—
Product	(R)-1-(5-bromo-2-(methylthio)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride	HCID 90312062	—

Reaction Steps

The title compound (11F) was prepared according to the method presented for the synthesis of compound 1F of Example 1 utilizing 11E. MS (m/z) 361.66 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09050344B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-3f79cf2465e645d090f8d855c1d7b50c
Source note	uspto-grants-2015_06