反应详情

Compound 11G (198 mg, 0.33 mmol) was charged in dichloromethane (2 ml) at 0° C. mCPBA (meta-chloroperoxybenzoic acid) (185 mg, 0.8 mmol, content 77 percent; 2.5 eq.) was added a little at a time. The mixture was slowly warmed to room temperature and stirred for 4 h and then water was added. The reaction mixture was partitioned between dichloromethane and saturated NaHCO3 aqueous solution. The organic layer was separated and concentrated to afford the title product. MS (m/z) 622.98 [M+H]+.

1. additionwas added a little at a time
2. customThe reaction mixture was partitioned between dichloromethane and saturated NaHCO3 aqueous solution
3. customThe organic layer was separated
4. concentrationconcentrated