HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-5-(2-((2-(1H-1,2,3-triazol-1-yl)ethyl)amino)-4-(1-amino-2-(3,5-difluorophenyl)ethyl)pyrimidin-5-yl)-2-fluorobenzamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-tert-butyl (1-(2-((2-(1H-1,2,3-triazol-1-yl)ethyl)amino)-5-(3-carbamoyl-4-fluorophenyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate | HCID 90290213 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-5-(2-((2-(1H-1,2,3-triazol-1-yl)ethyl)amino)-4-(1-amino-2-(3,5-difluorophenyl)ethyl)pyrimidin-5-yl)-2-fluorobenzamide hydrochloride | HCID 90281374 | — |
Reaction Steps
Compound 23D was dissolved in 2 mL of 4N HCl in dioxane and stirred at ambient temperature for overnight. The solvent was removed to afford the title product. (m/z) 483.08 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09050344B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-335e7a18856e47e5a91807562b90abcf |
| Source note | uspto-grants-2015_06 |