Hydrochloric Acid → (S)-5-(2-((2-(1H-1,2,3-triazol-1-yl)ethyl)amino)-4-(1-amino-2-(3,5-difluorophenyl)ethyl)pyrimidin-5-yl)-2-fluorobenzamide hydrochloride

HRID 2170349Notes

Reaction equation

HRID 2170349 reaction equation
[N:1]1([CH2:6][CH2:7][NH:8][C:9]2[N:14]=[C:13]([C@@H:15]([NH:25]C(=O)OC(C)(C)C)[CH2:16][C:17]3[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=3)[C:12]([C:33]3[CH:38]=[CH:37][C:36]([F:39])=[C:35]([C:40](=[O:42])[NH2:41])[CH:34]=3)=[CH:11][N:10]=2)[CH:5]=[CH:4][N:3]=[N:2]1.[ClH:43]>O1CCOCC1>[ClH:43].[N:1]1([CH2:6][CH2:7][NH:8][C:9]2[N:14]=[C:13]([C@@H:15]([NH2:25])[CH2:16][C:17]3[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=3)[C:12]([C:33]3[CH:38]=[CH:37][C:36]([F:39])=[C:35]([CH:34]=3)[C:40]([NH2:41])=[O:42])=[CH:11][N:10]=2)[CH:5]=[CH:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90290213(S)-tert-butyl (1-(2-((2-(1H-1,2,3-triazol-1-yl)ethyl)amino)-5-(3-carbamoyl-4-fluorophenyl)pyrimidin-4-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Product 1

HCID 90281374(S)-5-(2-((2-(1H-1,2,3-triazol-1-yl)ethyl)amino)-4-(1-amino-2-(3,5-difluorophenyl)ethyl)pyrimidin-5-yl)-2-fluorobenzamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound 23D was dissolved in 2 mL of 4N HCl in dioxane and stirred at ambient temperature for overnight. The solvent was removed to afford the title product. (m/z) 483.08 [M+H]+.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-335e7a18856e47e5a91807562b90abcf
Source dataset
uspto-grants-2015_06
Patent number
US09050344B2

Reaction notes

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