Trifluoroacetic acid → (S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	(S)-tert-butyl (1-(5-amino-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate	HCID 90290153	—
Solvent	Dichloromethane	HCID 6344	—
Product	(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt	HCID 131732937	—

Reaction Steps

Compound 49A (60 mg) was dissolved in 2 mL of DCM and to it was added 0.3 mL of TFA. The reaction mixture was stirred at room temperature for 1 hour. The solvent was removed to afford the title product. MS (m/z): 507.00 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09050344B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-d74f150e0da74db3a3dabf43f34b9feb
Source note	uspto-grants-2015_06