Trifluoroacetic acid → (S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

HRID 2170387Notes

Reaction equation

HRID 2170387 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:26]2[CH:27]=[CH:28][C:29]([Cl:41])=[C:30]3[C:34]=2[N:33]([CH3:35])[N:32]=[C:31]3[NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[C:5]([C@@H:8]([NH:18]C(=O)OC(C)(C)C)[CH2:9][C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=2)=[N:6][CH:7]=1.[C:42]([OH:48])([C:44]([F:47])([F:46])[F:45])=[O:43]>C(Cl)Cl>[OH:48][C:42]([C:44]([F:47])([F:46])[F:45])=[O:43].[NH2:1][C:2]1[CH:3]=[C:4]([C:26]2[CH:27]=[CH:28][C:29]([Cl:41])=[C:30]3[C:34]=2[N:33]([CH3:35])[N:32]=[C:31]3[NH:36][S:37]([CH3:40])(=[O:39])=[O:38])[C:5]([C@@H:8]([NH2:18])[CH2:9][C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 90290153(S)-tert-butyl (1-(5-amino-3-(4-chloro-1-methyl-3-(methylsulfonamido)-1H-indazol-7-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)carbamate

Product 1

HCID 131732937(S)-N-(7-(5-amino-2-(1-amino-2-(3,5-difluorophenyl)ethyl)pyridin-3-yl)-4-chloro-1-methyl-1H-indazol-3-yl)methanesulfonamide TFA salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 49A (60 mg) was dissolved in 2 mL of DCM and to it was added 0.3 mL of TFA. The reaction mixture was stirred at room temperature for 1 hour. The solvent was removed to afford the title product. MS (m/z): 507.00 [M+H]+.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-d74f150e0da74db3a3dabf43f34b9feb
Source dataset
uspto-grants-2015_06
Patent number
US09050344B2

Reaction notes

Loading…