p-Toluenesulfonic acid → HCID 89580873, compound

HRID 2170514Notes

Reaction equation

HRID 2170514 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][CH:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)[CH3:11].C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[OH:7][CH2:8][CH2:9][CH:10]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:20][CH:21]=1)[CH3:11]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 89580683HCID 89580683, compound

Product 1

HCID 89580873HCID 89580873, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the solution of methyl 4-(4-(tetrahydro-2H-pyran-2-yloxy)butan-2-yl)benzoate (501.8 mg 1.72 mmol) in methanol (60 mL) was added p-toluenesulfonic acid (592 mg, 3.44 mmol). the solution was stirred for 12 hours, then the solvent was remove and dissolved in dichloromethane (50 ml) and washed water, dried with sodium sulfate, concentrated to give methyl 4-(4-hydroxybutan-2-yl)benzoate (354 mg, 99%).

Workup

  1. customthe solvent was remove
  2. dissolutiondissolved in dichloromethane (50 ml)
  3. washwashed water
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-f9772017fa7849f88c32b0a2ff838f94
Source dataset
uspto-grants-2015_06
Patent number
US09051269B2

Reaction notes

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