HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-(7-Methoxy-3,4-dihydro-naphthalen-2-yl)-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 7-Hydroxy-2-tetralone | HCID 4198875 | — |
| Product | 1-(7-Methoxy-3,4-dihydro-naphthalen-2-yl)-pyrrolidine | HCID 12264684 | — |
Reaction Steps
Under N2 atmosphere, a solution of 7-hydroxy-3,4-dihydro-1H-naphthalen-2-one (85 g, 0.48 mol) and pyrrolidine (264 g, 1.5 mol) in MeOH (3000 mL) was stirred at room temperature for 2 hrs. The solvent was removed in vacuo to give crude 1-(7-methoxy-3,4-dihydro-naphthalen-2-yl)-pyrrolidine (320 g) which was directly used for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051280B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d1bec900e85846d6a2dbe425590a1f52 |
| Source note | uspto-grants-2015_06 |