反应详情

2-(4-Chloro-phenyl)-5-methyl-3H-pyrimidin-4-one (570 mg, 2.58 mmol) was suspended in phosphorus oxychloride (2 ml) and heated to reflux for 2 hours. The mixture was cooled before being stripped to dryness in vacuo. The resulting crude product was solubilised in water (10 ml) and ethyl acetate (10 ml) and the biphasic mixture separated. The aqueous layer was further extracted with ethyl acetate (10 ml) before the combined organics were dried with magnesium sulphate, filtered and stripped to dryness in vacuo to give 6-Chloro-2-(4-chloro-phenyl)-5-methyl-1,6-dihydro-pyrimidine as a white solid (567 mg, 2.38 mmol, 92% yield).

1. temperatureheated
2. temperatureto reflux for 2 hours
3. temperatureThe mixture was cooled
4. customethyl acetate (10 ml) and the biphasic mixture separated
5. extractionThe aqueous layer was further extracted with ethyl acetate (10 ml) before the combined
6. dry with materialorganics were dried with magnesium sulphate
7. filtrationfiltered