4-(Trifluoromethoxy)thiophenol → HCID 18538977, compound

HRID 2170845Notes

Reaction equation

HRID 2170845 reaction equation
CS(O[CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)(=O)=O.[F:19][C:20]([F:30])([F:29])[O:21][C:22]1[CH:27]=[CH:26][C:25]([SH:28])=[CH:24][CH:23]=1>>[F:30][C:20]([F:19])([F:29])[O:21][C:22]1[CH:23]=[CH:24][C:25]([S:28][CH:6]2[CH2:7][CH2:8][N:9]([C:12]([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:13])[CH2:10][CH2:11]2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 27773604-(Trifluoromethoxy)thiophenolHCID 41848691-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine

Product 1

HCID 18538977HCID 18538977, compoundYield 41%

Procedure

The title compound was prepared in 41% yield (0.66 g, colorless oil) from tert-butyl 4-((methylsulfonyl)oxy)piperidine-1-carboxylate (1.20 g, 4.30 mmol) and 4-(trifluoromethoxy)benzenethiol (1.00 g, 5.15 mmol) by the similar manner in Step-1 of Intermediate-4.

Sources & evidence

ORD record
ord-39abf1cf041f41b08cbf0b7839dcf6dc
Source dataset
uspto-grants-2015_06
Patent number
US09051296B2

Reaction notes

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