O-Methylhydroxylamine hydrochloride → HCID 86654647, compound

HRID 2170882Notes

Reaction equation

HRID 2170882 reaction equation
[C:1]1([C:7]2[CH:11]=[CH:10][N:9]([C:12]3[N:34]=[CH:33][CH:32]=[CH:31][C:13]=3[C:14]([NH:16][CH:17]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=3)[CH:18]([OH:22])[C:19]([OH:21])=O)=[O:15])[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:36][O:37][NH2:38]>>[F:30][C:26]1[CH:25]=[C:24]([CH2:23][CH:17]([NH:16][C:14](=[O:15])[C:13]2[CH:31]=[CH:32][CH:33]=[N:34][C:12]=2[N:9]2[CH:10]=[CH:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:8]2)[CH:18]([OH:22])[C:19]([NH:38][O:37][CH3:36])=[O:21])[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 67239118HCID 67239118, compound

Product 1

HCID 86654647HCID 86654647, compound

Procedure

The reaction was carried out in analogy to reaction step 1.3 by reacting 3-(2-(3-phenyl-1H-pyrazol-1-yl)nicotinamido)-2-hydroxy-4-(3-fluorophenyl)-butanoic acid with O-methylhydroxylamine hydrochloride. ESI-MS [M+H]+: 490.2

Workup

  1. customThe reaction was carried out in analogy to reaction step 1.3

Sources & evidence

ORD record
ord-22abbf0e91c74e7495867b5af1fe6cb7
Source dataset
uspto-grants-2015_06
Patent number
US09051304B2

Reaction notes

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