Sodium Hydroxide → {(S)-6-[(R)-4-Morpholin-4-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

HRID 2170937Notes

Reaction equation

HRID 2170937 reaction equation
C[O:2][C:3](=[O:35])[CH2:4][C@H:5]1[C:9]2[CH:10]=[CH:11][C:12]([O:14][C@H:15]3[C:23]4[C:18](=[C:19]([CH2:28][N:29]5[CH2:34][CH2:33][O:32][CH2:31][CH2:30]5)[C:20]([C:24]([F:27])([F:26])[F:25])=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)=[CH:13][C:8]=2[O:7][CH2:6]1.[OH-].[Na+]>CO>[N:29]1([CH2:28][C:19]2[C:20]([C:24]([F:25])([F:27])[F:26])=[CH:21][CH:22]=[C:23]3[C:18]=2[CH2:17][CH2:16][C@H:15]3[O:14][C:12]2[CH:11]=[CH:10][C:9]3[C@H:5]([CH2:4][C:3]([OH:35])=[O:2])[CH2:6][O:7][C:8]=3[CH:13]=2)[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 90313207{(S)-6-[(R)-4-Morpholin-4-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl}-acetic acid methyl ester

Product 1

HCID 90314216{(S)-6-[(R)-4-Morpholin-4-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is prepared from {(S)-6-[(R)-4-morpholin-4-ylmethyl-5-trifluoromethyl-indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl}-acetic acid methyl ester by saponification with aq. NaOH in methanol as described above for Examples 1-11.

Sources & evidence

ORD record
ord-99a7b5245b6e473fb1fcca1d21e1f3b7
Source dataset
uspto-grants-2015_06
Patent number
US09051289B2

Reaction notes

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