反应详情

温度

15 °C

A mixture of compound 6-c (6 g, 17.4 mmol) and Cs2CO3 (CAS 534-17-8) (17 g, 52.2 mmol) in methanol (70 mL) and THF (140 mL) was stirred at 15° C. for 12 h. The solvent was removed under vacuum. H2O (30 mL) was added and the mixture was extracted with ethyl acetate (30 mL×3). The organic layer was washed with brine and dried over Na2SO4. The solvent was evaporated under vacuum to yield product 6-d as a white powder (1.39 g, 46%).

1. customThe solvent was removed under vacuum
2. additionH2O (30 mL) was added
3. extractionthe mixture was extracted with ethyl acetate (30 mL×3)
4. washThe organic layer was washed with brine
5. dry with materialdried over Na2SO4
6. customThe solvent was evaporated under vacuum
7. customto yield product 6-d as a white powder (1.39 g, 46%)