反应详情

To a stirring solution of 2,3-dimethoxy-phenol (6 g, 38.70 mmol) in tetrahydrofuran (30 mL) at 25° C., was added N-bromosuccinimide (6.89 g, 38.70 mmol) and the resultant reaction mixture was stirred at RT for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate (3×). The combined ethyl acetate layer was washed with brine and dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 6-Bromo-2,3-dimethoxyphenol as a solid.

1. customthe resultant reaction mixture
2. extractionextracted with ethyl acetate (3×)
3. washThe combined ethyl acetate layer was washed with brine
4. dry with materialdried over anhydrous sodium sulphate
5. concentrationconcentrated under reduced pressure