反应详情

温度

-78 °C

To a stirring solution of 1-bromo-3,4-dimethoxy-2-methoxymethoxy-benzene (1 g, 3.62 mmol) in tetrahydrofuran (15 mL) at −78° C., was added n-butyllithium (5.5 mL, 7.24 mmol) and stirred for 20 min to this trimethylborate (3.76 g, 36.23 mmol) was added and the resultant reaction mixture was stirred for 30 min at −78° C. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate (3×). The combined ethyl acetate layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 3,4-dimethoxy-2-(methoxymethyl)phenylboronic acid as a solid.

1. additionwas added
2. customthe resultant reaction mixture
3. customThe reaction mixture was quenched with saturated ammonium chloride solution
4. extractionextracted with ethyl acetate (3×)
5. washThe combined ethyl acetate layer was washed with brine
6. dry with materialdried over anhydrous sodium sulphate
7. concentrationconcentrated under reduced pressure