反应详情

温度

90 °C

To a stirring solution of 3,4-dimethoxy-2-(methoxymethyl)phenylboronic acid (compound 301) (400 mg, 1.88 mmol) in dimethylformamide (10 mL) under nitrogen atmosphere, were added cesium carbonate (1.8 g, 5.66 mmol), tetrakis(triphenylphosphine)palladium(0) (100 mg, 0.09 mmol) and 5-bromoisoindolin-1-one (913 mg, 3.77 mmol) and the resultant reaction mixture was heated to 90° C. for 6 h. The reaction mixture was filtered off and the filtrate was extracted with ethyl acetate (3×). The combined ethyl acetate layer was washed with brine and dried over anhydrous sodium sulphate and concentrated under reduced pressure. Purification was done by column chromatography (silica gel, 0-3% methanol in dichloromethane) afforded 5-(3,4-dimethoxy-2-(methoxymethoxy)phenyl)isoindolin-1-one as a solid.

1. customthe resultant reaction mixture
2. filtrationThe reaction mixture was filtered off
3. extractionthe filtrate was extracted with ethyl acetate (3×)
4. washThe combined ethyl acetate layer was washed with brine
5. dry with materialdried over anhydrous sodium sulphate
6. concentrationconcentrated under reduced pressure
7. customPurification