Butyryl chloride → HCID 71279602, compound

HRID 2171025Notes

Reaction equation

HRID 2171025 reaction equation
[NH2:1][CH2:2][C:3]1([CH2:6][O:7][C:8]2[C:13]([O:14][CH3:15])=[C:12]([O:16][CH3:17])[CH:11]=[CH:10][C:9]=2[C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[CH2:5][CH2:4]1.C(N(C(C)C)CC)(C)C.[C:37](Cl)(=[O:41])[CH2:38][CH2:39][CH3:40]>ClCCl>[CH3:15][O:14][C:13]1[C:12]([O:16][CH3:17])=[CH:11][CH:10]=[C:9]([C:18]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:19]=2[CH2:20][CH2:21][C:22]3=[O:27])[C:8]=1[O:7][CH2:6][C:3]1([CH2:2][NH:1][C:37](=[O:41])[CH2:38][CH2:39][CH3:40])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 8855Butyryl chlorideHCID 81531DiisopropylethylamineHCID 71279377HCID 71279377, compound2×

Product 1

HCID 71279602HCID 71279602, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 4-[2-(1-Aminomethyl-cyclopropylmethoxy)-3,4-dimethoxy-phenyl]-indan-1-one (Compound 182) (100 mg, 0.272 mmol) in dichloromethane (10 mL), were added diisopropylethylamine (0.034 g, 0.272 mmol) and butyryl chloride (29 mg, 0.272 mmol) and the resultant reaction mixture was subjected to the conditions used in the preparation of compound 183 to afford the title compound as a solid.

Workup

  1. customthe resultant reaction mixture

Sources & evidence

ORD record
ord-43893b578d1e44e2b78058e9986427ff
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

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