反应详情

To a stirring solution of 4-[2-(3-Aminomethyl-oxetan-3-ylmethoxy)-3,4-dimethoxy-phenyl]-indan-1-one (Compound 191) (150 mg, 0.391 mmol) in dichloromethane (15 mL), were added triethylamine (118 mg, 1.174 mmol) and acetyl chloride (61 mg, 0.777 mmol) and the resultant reaction mixture was stirred at RT for 16 h. The reaction mixture was diluted with water and extracted with dichloromethane (3×). The combined dichloromethane layer was washed with brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure. Purification by column chromatography (silica gel, 0-2% methanol in dichloromethane) afforded the title compound as a solid.

1. customthe resultant reaction mixture
2. extractionextracted with dichloromethane (3×)
3. washThe combined dichloromethane layer was washed with brine
4. dry with materialdried over anhydrous sodium sulphate
5. concentrationconcentrated under reduced pressure
6. customPurification by column chromatography (silica gel, 0-2% methanol in dichloromethane)