Propylamine → HCID 67468015, compound

HRID 2171051Notes

Reaction equation

HRID 2171051 reaction equation
[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][CH:27]=2)[C:24](=[O:28])[CH2:23][CH2:22]3)[C:4]=1[O:5][CH2:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=O.[CH2:29]([NH2:32])[CH2:30][CH3:31].COC1C(OC)=CC=C(C2C=C3C(=CC=2)C(=O)CC3)C=1OCC(C)(C)C(NC)=O>>[CH3:1][O:2][C:3]1[C:16]([O:17][CH3:18])=[CH:15][CH:14]=[C:13]([C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][CH:27]=2)[C:24](=[O:28])[CH2:23][CH2:22]3)[C:4]=1[O:5][CH2:6][C:7]([CH3:11])([CH3:12])[C:8]([NH:32][CH2:29][CH2:30][CH3:31])=[O:10]

Participants

4

Reactant 3

HCID 7852PropylamineHCID 67466869HCID 67466869, compound2×HCID 67468017HCID 67468017, compound

Product 1

HCID 67468015HCID 67468015, compound

Procedure

From 3-[2,3-Dimethoxy-6-(1-oxo-indan-5-yl)-phenoxy]-2,2-dimethyl-propionic acid (Compound 205) and propan-1-amine following the procedure for preparation of Compound 206. Purification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether) afforded the title compound as a solid.

Workup

  1. customPurification by column chromatography (silica gel, 0-50% ethyl acetate in pet ether)

Sources & evidence

ORD record
ord-7def44438e604a9d9e9ffece4ae53db9
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

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