反应详情

温度

50 °C

To a stirring solution of 4-(4-(difluoromethoxy)-3-methoxy-2-(methoxymethoxy)phenyl)-2,3-dihydro-1H-inden-1-one (1 g, 2.74 mmol) in methanol (75 mL) was added concentrated hydrochloride (5 mL) and the reaction mixture was heated to 50° C. for 1 h. The reaction mixture was cooled to RT and concentrated under reduced pressure and the obtained residue was basified with sodium bicarbonate solution and extracted with dichloromethane (3×). The combined dichloromethane layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as a solid (700 mg, 80%).

1. temperatureThe reaction mixture was cooled to RT
2. concentrationconcentrated under reduced pressure
3. extractionextracted with dichloromethane (3×)
4. washThe combined dichloromethane layers were washed with brine
5. dry with materialdried over sodium sulphate
6. concentrationconcentrated under reduced pressure