反应详情

温度

80 °C

To a stirring solution of 4-(4-(difluoromethoxy)-2-hydroxy-3-methoxyphenyl)-2,3-dihydro-1H-inden-1-one (75 mg, 0.234 mmol) in acetonitrile (10 mL) was added potassium carbonate (96.8 mg, 0.702 mmol) and 3-bromomethyl-3-methyl-oxetane (115 mg, 0.702 mmol) and the resultant reaction mixture was heated to 80° C. for 16 h. The reaction mixture was cooled to RT and filtered through celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, 0-20% ethyl acetate in pet ether) to afford title compound as a solid (25 mg, 26%).

1. customthe resultant reaction mixture
2. temperatureThe reaction mixture was cooled to RT
3. filtrationfiltered through celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was purified by column chromatography (silica gel, 0-20% ethyl acetate in pet ether)