反应详情

温度

80 °C

To a stirring solution of 6-bromo-3-(difluoromethoxy)-2-methoxyphenol (0.3 g, 1.11 mmol) in acetonitrile (10 mL) was added potassium carbonate (0.46 g, 3.34 mmol) and followed by 3-(bromomethyl)-3-(methoxymethyl)oxetane (0.43 g, 2.22 mmol) and the resultant reaction mixture was heated to 80° C. for 16 h. The reaction mixture was cooled to RT, filtered through celite and the filtrate was concentrated under reduced pressure to afford 3-((6-bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)-3-(methoxymethyl)oxetane as a solid (0.3 g, 70%).

1. customthe resultant reaction mixture
2. temperatureThe reaction mixture was cooled to RT
3. filtrationfiltered through celite
4. concentrationthe filtrate was concentrated under reduced pressure