Hydrochloric Acid → Methyl 4-bromo-2-methylbenzoate

Participants

Reaction Conditions

Reaction Steps

To a stirring solution of 4-bromo-2-methylbenzoic acid (3 g) in methanol (70 mL) was added concentrated hydrochloric acid (5 mL) and the reaction mixture was heated to 60° C. for 16 h. The reaction mixture was concentrated under reduced pressure, the residue was basified with sodium bicarbonate solution and extracted with dichloromethane (3×). The combined dichloromethane layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford Methyl 4-bromo-2-methylbenzoate as a solid (2 g, 62%).

Provenance & Evidence