Hydrochloric Acid → Methyl 4-bromo-2-methylbenzoate

Temperature

60 °C

To a stirring solution of 4-bromo-2-methylbenzoic acid (3 g) in methanol (70 mL) was added concentrated hydrochloric acid (5 mL) and the reaction mixture was heated to 60° C. for 16 h. The reaction mixture was concentrated under reduced pressure, the residue was basified with sodium bicarbonate solution and extracted with dichloromethane (3×). The combined dichloromethane layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford Methyl 4-bromo-2-methylbenzoate as a solid (2 g, 62%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionextracted with dichloromethane (3×)
3. washThe combined dichloromethane layers were washed with brine
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under reduced pressure

ORD record

ord-2de2810c97304755a5406714a2308167

Source dataset

uspto-grants-2015_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09051290B2