Cesium carbonate → HCID 67465354, compound

HRID 2171104Notes

Reaction equation

HRID 2171104 reaction equation
Br[C:2]1[C:7]([O:8][CH2:9][C:10]2([CH3:14])[CH2:13][O:12][CH2:11]2)=[C:6]([O:15][CH3:16])[C:5]([O:17][CH:18]([F:20])[F:19])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Cs+].[Cs+].CC1(C)C(C)(C)OB([C:35]2[CH:36]=[C:37]3[C:41](=[CH:42][CH:43]=2)[C:40](=[O:44])[NH:39][CH2:38]3)O1>CN(C)C=O.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[F:19][CH:18]([F:20])[O:17][C:5]1[CH:4]=[CH:3][C:2]([C:35]2[CH:36]=[C:37]3[C:41](=[CH:42][CH:43]=2)[C:40](=[O:44])[NH:39][CH2:38]3)=[C:7]([O:8][CH2:9][C:10]2([CH3:14])[CH2:13][O:12][CH2:11]2)[C:6]=1[O:15][CH3:16]

Participants

6

Reactant 3

HCID 10796Cesium carbonateHCID 219557955-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-oneHCID 67462991HCID 67462991, compound

Product 1

HCID 67465354HCID 67465354, compoundYield 22%

Reagents, catalysts & solvents 2

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
85 °C

Procedure

To a stirring solution of 3-((6-bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)-3-methyloxetane (200 mg, 0.566 mmol) in dimethylformamide (10 mL) was purged with argon for 1 h. To this cesium carbonate (551 mg, 1.698 mmol), tetrakis(triphenylphosphine) palladium(0) (32 mg, 0.028 mmol) and 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one (176 mg, 0.679 mmol) were added and the resultant reaction mixture was heated to 80-90° C. for 3 h. The reaction mixture was cooled to RT, filtered and the filtrate was diluted with water and extracted with ethyl acetate (3×). The combined ethyl acetate layer was washed with brine and dried over anhydrous sodium sulphate and concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel, 0-20% ethyl acetate in pet ether) afforded the title compound as a solid (50 mg, 22%).

Workup

  1. customthe resultant reaction mixture
  2. temperatureThe reaction mixture was cooled to RT
  3. filtrationfiltered
  4. additionthe filtrate was diluted with water
  5. extractionextracted with ethyl acetate (3×)
  6. washThe combined ethyl acetate layer was washed with brine
  7. dry with materialdried over anhydrous sodium sulphate
  8. concentrationconcentrated under reduced pressure
  9. customPurification of the residue by column chromatography (silica gel, 0-20% ethyl acetate in pet ether)

Sources & evidence

ORD record
ord-2ceff832c278400191e5ad467a18063a
Source dataset
uspto-grants-2015_06
Patent number
US09051290B2

Reaction notes

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