反应详情

To a stirring solution of 4-bromo-2-methoxybenzene-1,3-diol (4.5 g, 20.54 mmol) in acetone (40 mL) at 0° C. was added potassium carbonate (2.83 g, 20.54 mmol) and methoxymethyl chloride (1.32 g, 17.39 mmol). The resultant reaction mixture was stirred at RT for 7 h. The reaction mixture was quenched with ice-cold water, the solid was filtered and the filtrate was concentrated under reduced pressure to leave a residue having the crude product. The crude product was purified by column chromatography (silica gel, 0-10% ethyl acetate in pet ether) to afford 4-Bromo-2-methoxy-3-(methoxymethoxy)phenol as a liquid (2 g, 37%).

1. customThe resultant reaction mixture
2. customThe reaction mixture was quenched with ice-cold water
3. filtrationthe solid was filtered
4. concentrationthe filtrate was concentrated under reduced pressure
5. customto leave a residue
6. customThe crude product was purified by column chromatography (silica gel, 0-10% ethyl acetate in pet ether)