反应详情

温度

50 °C

To a stirring solution of 5-(4-ethoxy-3-methoxy-2-(methoxymethoxy)phenyl)isobenzofuran-1(3H)-one (100 mg, 0.292 mmol) in methanol (5 mL) was added conc. hydrochloric acid (0.5 mL) and heated to 50° C. for 1 h. The reaction mixture was concentrated under reduced pressure; the residue was basified with sodium bicarbonate solution and extracted with ethyl acetate (3×). The combined ethyl acetate layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as a solid (60 mg, 68%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionextracted with ethyl acetate (3×)
3. washThe combined ethyl acetate layers were washed with brine
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under reduced pressure