反应详情

温度

80 °C

To a stirring solution of 4-(3-hydroxy-2,4-dimethoxyphenyl)-2,3-dihydro-1H-inden-1-one (80 mg, 0.281 mmol) in acetonitrile (5 mL) was added potassium carbonate (115 mg, 0.843 mmol) and (3-(bromomethyl)oxetan-3-yl)methanol (153 mg, 0.843 mmol) and the resultant reaction mixture was heated to 80° C. for 4 h. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The obtained residue was purified by column chromatography (silica gel, 0-50% ethyl acetate in pet ether) to afford the title compound as a solid (30 mg, 27.6%).

1. customthe resultant reaction mixture
2. filtrationThe reaction mixture was filtered through celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe obtained residue was purified by column chromatography (silica gel, 0-50% ethyl acetate in pet ether)