反应详情

To a stirring solution of 3-bromo-6-methoxybenzene-1,2-diol (500 mg, 2.28 mmol) in acetone (40 mL) at 0° C. was added potassium carbonate (314 mg, 2.28 mmol) and methoxymethyl chloride (184 mg, 2.28 mmol) and the resultant reaction mixture was stirred at RT for 2 h. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure Purification by column chromatography (silica gel, 0-8% ethyl acetate in pet ether) afforded 3-Bromo-6-methoxy-2-(methoxymethoxy)phenol as a liquid (230 mg, 38%).

1. customthe resultant reaction mixture
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated under reduced pressure Purification by column chromatography (silica gel, 0-8% ethyl acetate in pet ether)