反应详情

To a stirring solution of 4-(3-(cyclopropylmethoxy)-4-methoxy-2-(methoxymethoxy)phenyl)-2,3-dihydro-1H-inden-1-one (1.5 g, 4.076 mmol) in methanol (25 mL) was added concentrated hydrochloride (5 mL) and the reaction mixture was stirred at RT for 2 h. The reaction mixture was concentrated under reduced pressure the obtained residue was basified with sodium bicarbonate solution and extracted with dichloromethane (3×). The combined dichloromethane layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as a solid (1 g, 75.7%).

1. concentrationThe reaction mixture was concentrated under reduced pressure the obtained residue
2. extractionextracted with dichloromethane (3×)
3. washThe combined dichloromethane layers were washed with brine
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under reduced pressure