反应详情

To a stirring solution of 5-(3-(cyclopropylmethoxy)-4-methoxy-2-(methoxymethoxy)phenyl)isobenzofuran-1(3H)-one (1.5 g, 4.05 mmol) in methanol (25 mL) was added concentrated hydrochloride (5 mL) and the reaction mixture was stirred for 2 h at RT. The reaction mixture was concentrated under reduced pressure and the obtained residue was basified with sodium bicarbonate solution and then extracted with dichloromethane (3×). The combined dichloromethane layers were washed with brine, dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as a solid (1 g, 76%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. extractionextracted with dichloromethane (3×)
3. washThe combined dichloromethane layers were washed with brine
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under reduced pressure