Hydrochloric Acid → HCID 72207560, compound

HRID 2171220Notes

Reaction equation

HRID 2171220 reaction equation
[OH-].[K+].CCO.[CH3:6][O:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=2)[N:10](C(OCC)=O)[N:9]=1.Cl>O>[CH3:6][O:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([N+:17]([O-:19])=[O:18])[CH:15]=2)[NH:10][N:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 89666817HCID 89666817, compound

Product 1

HCID 72207560HCID 72207560, compoundYield 70.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium hydroxide (0.6 g) was added to an EtOH (20 ml) solution containing ethyl 3-methoxy-5-nitro-1H-indazol-1-carboxylate (1.24 g) obtained in the 3rd step, followed by stirring at room temperature for 0.5 hours. Water and concentrated hydrochloric acid (1 ml) were added dropwise to the reaction solution. A solid precipitate was collected by filtration and washed with water. A light yellow solid of 3-methoxy-5-nitro-1H-indazole (636 mg) was thus obtained.

Workup

  1. customobtained in the 3rd step
  2. filtrationA solid precipitate was collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-2736a9bb487e421a8acc2b81e709ee69
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

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