Hydrazine hydrate (1:1) → HCID 178526733, compound

HRID 2171225Notes

Reaction equation

HRID 2171225 reaction equation
O.[NH2:2][NH2:3].F[C:5]1[C:14]([F:15])=[CH:13][C:12]([N+:16]([O-:18])=[O:17])=[CH:11][C:6]=1[C:7](OC)=[O:8]>CCO>[F:15][C:14]1[CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=[C:6]2[C:5]=1[NH:3][N:2]=[C:7]2[OH:8]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 62662214Methyl 2,3-difluoro-5-nitrobenzoate

Product 1

HCID 178526733HCID 178526733, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine monohydrate (1.91 ml) was added to an EtOH (40 ml) solution containing methyl 2,3-difluoro-5-nitrobenzoate (1.71 g) obtained in the 2nd step, followed by stirring at room temperature for 10 minutes. An insoluble precipitate was removed by filtration and washed with EtOH. 7-Fluoro-5-nitro-1H-indazol-3-ol (956 mg) was thus obtained.

Workup

  1. customobtained in the 2nd step
  2. customAn insoluble precipitate was removed by filtration
  3. washwashed with EtOH

Sources & evidence

ORD record
ord-5f04ab7b82c84aac8f7bc3970ae57cac
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

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