Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Nitroindazole | HCID 21501 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178526495 | HCID 178526495 | 90.3% |
Reaction Steps
Potassium hydroxide (6.45 g) and iodine (15.6 g) were added to a DMF (60 ml) solution containing 5-nitroindazole (5 g), followed by stirring at 65° C. for 1 hour. The reaction solution was poured into a saturated sodium hydrogen carbonate aqueous solution and a solid precipitate was collected by filtration. 3-Iodo-5-nitro-1H-indazole (8 g) was thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09051310B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-6d5e914bf9ea49f2994512332b310ef2 |
|---|
| Source note | uspto-grants-2015_06 |
|---|
