Iodine → HCID 178526495, compound

HRID 2171237Notes

Reaction equation

HRID 2171237 reaction equation
[OH-].[K+].[I:3]I.[N+:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][N:12]=[CH:11]2)([O-:7])=[O:6].C(=O)([O-])O.[Na+]>CN(C=O)C>[I:3][C:11]1[C:10]2[C:14](=[CH:15][CH:16]=[C:8]([N+:5]([O-:7])=[O:6])[CH:9]=2)[NH:13][N:12]=1

Participants

6

Reactant 4

HCID 807IodineHCID 14797Potassium HydroxideHCID 215015-NitroindazoleHCID 516892Sodium Bicarbonate

Product 1

HCID 178526495HCID 178526495, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
65 °C

Procedure

Potassium hydroxide (6.45 g) and iodine (15.6 g) were added to a DMF (60 ml) solution containing 5-nitroindazole (5 g), followed by stirring at 65° C. for 1 hour. The reaction solution was poured into a saturated sodium hydrogen carbonate aqueous solution and a solid precipitate was collected by filtration. 3-Iodo-5-nitro-1H-indazole (8 g) was thus obtained.

Workup

  1. filtrationa solid precipitate was collected by filtration

Sources & evidence

ORD record
ord-6d5e914bf9ea49f2994512332b310ef2
Source dataset
uspto-grants-2015_06
Patent number
US09051310B2

Reaction notes

Loading…